Bridging The Two Worlds: A Universal Interface Between Enzymatic And Dna Computing Systems

Keywords

deoxyribozymes; electrochemistry; enzyme computation; molecular computation; NADH

Abstract

Molecular computing based on enzymes or nucleic acids has attracted a great deal of attention due to the perspectives of controlling living systems in the way we control electronic computers. Enzyme-based computational systems can respond to a great variety of small molecule inputs. They have the advantage of signal amplification and highly specific recognition. DNA computing systems are most often controlled by oligonucleotide inputs/outputs and are capable of sophisticated computing as well as controlling gene expressions. Here, we developed an interface that enables communication of otherwise incompatible nucleic-acid and enzyme-computational systems. The enzymatic system processes small molecules as inputs and produces NADH as an output. The NADH output triggers electrochemical release of an oligonucleotide, which is accepted by a DNA computational system as an input. This interface is universal because the enzymatic and DNA computing systems are independent of each other in composition and complexity. Interface development: The communication between enzymatic and DNA logic systems was enabled by the development of a corresponding interface.

Publication Date

5-1-2015

Publication Title

Angewandte Chemie - International Edition

Volume

54

Issue

22

Number of Pages

6562-6566

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/anie.201411148

Socpus ID

84927622579 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84927622579

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