Tailoring The Surface Of Liquid Crystal Droplets With Chitosan/Surfactant Complexes For The Selective Detection Of Bile Acids In Biological Fluids

Abstract

We report an approach for tailoring the surface of 4-n-pentyl-4′-cyanobiphenyl (5CB) droplets by the adsorption of chitosan (CHI) at the 5CB/aqueous interface, followed by the penetration of sodium tetradecyl sulfate (SC14S). The CHI/SC14S complex-coated 5CB droplets can be used as optical probes for the detection of cholic acid (CA) in phosphate-buffered saline and urine without dilution. We find that the CHI coating can significantly reduce the detection limit of 5CB droplets for CA. By controlling the number of CHI/SC14S complex-coated 5CB droplets, the detection limit for CA can be changed from ∼75 μM to ∼0.5 μM, which covers the concentration range of CA in individual urine with and without intestinal diseases.

Publication Date

8-11-2015

Publication Title

RSC Advances

Volume

5

Issue

86

Number of Pages

70094-70100

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/c5ra09937d

Socpus ID

84940508155 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84940508155

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