Cationic Surface Modification Of Gold Nanoparticles For Enhanced Cellular Uptake And X-Ray Radiation Therapy
Abstract
A challenge of X-ray radiation therapy is that high dose X-ray can damage normal cells and cause side effects. This paper describes a new nanoparticle-based method to reduce X-ray dose in radiation therapy by internalization of gold nanoparticles that are modified with cationic molecules into cancer cells. A cationic thiol molecule is synthesized and used to modify gold nanoparticles in a one-step reaction. The modified nanoparticles can penetrate cell membranes at high yield. By bringing radio-sensitized gold nanoparticles closer to nuclei where DNA is stored, the total X-ray dose needed to kill cancer cells has been reduced. The simulation of X-ray-gold nanoparticle interaction also indicates that Auger electrons contribute more than photoelectrons.
Publication Date
8-17-2015
Publication Title
Journal of Materials Chemistry B
Volume
3
Issue
37
Number of Pages
7372-7376
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1039/c5tb00766f
Copyright Status
Unknown
Socpus ID
84941913168 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84941913168
STARS Citation
Wang, Chaoming; Sun, An; Qiao, Yong; Zhang, Peipei; and Ma, Liyuan, "Cationic Surface Modification Of Gold Nanoparticles For Enhanced Cellular Uptake And X-Ray Radiation Therapy" (2015). Scopus Export 2015-2019. 1136.
https://stars.library.ucf.edu/scopus2015/1136
