Cationic Surface Modification Of Gold Nanoparticles For Enhanced Cellular Uptake And X-Ray Radiation Therapy

Abstract

A challenge of X-ray radiation therapy is that high dose X-ray can damage normal cells and cause side effects. This paper describes a new nanoparticle-based method to reduce X-ray dose in radiation therapy by internalization of gold nanoparticles that are modified with cationic molecules into cancer cells. A cationic thiol molecule is synthesized and used to modify gold nanoparticles in a one-step reaction. The modified nanoparticles can penetrate cell membranes at high yield. By bringing radio-sensitized gold nanoparticles closer to nuclei where DNA is stored, the total X-ray dose needed to kill cancer cells has been reduced. The simulation of X-ray-gold nanoparticle interaction also indicates that Auger electrons contribute more than photoelectrons.

Publication Date

8-17-2015

Publication Title

Journal of Materials Chemistry B

Volume

3

Issue

37

Number of Pages

7372-7376

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/c5tb00766f

Socpus ID

84941913168 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84941913168

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