Disease Invasion On Community Networks With Environmental Pathogen Movement

Keywords

Basic reproduction number; Cholera; Group inverse; Spanning trees; Waterborne disease

Abstract

The ability of disease to invade a community network that is connected by environmental pathogen movement is examined. Each community is modeled by a susceptible–infectious–recovered (SIR) framework that includes an environmental pathogen reservoir, and the communities are connected by pathogen movement on a strongly connected, weighted, directed graph. Disease invasibility is determined by the basic reproduction number R0 for the domain. The domain R0 is computed through a Laurent series expansion, with perturbation parameter corresponding to the ratio of the pathogen decay rate to the rate of water movement. When movement is fast relative to decay, R0 is determined by the product of two weighted averages of the community characteristics. The weights in these averages correspond to the network structure through the rooted spanning trees of the weighted, directed graph. Clustering of disease “hot spots” influences disease invasibility. In particular, clustering hot spots together according to a generalization of the group inverse of the Laplacian matrix facilitates disease invasion.

Publication Date

4-1-2015

Publication Title

Journal of Mathematical Biology

Volume

70

Issue

5

Number of Pages

1065-1092

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s00285-014-0791-x

Socpus ID

84939876007 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84939876007

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