Intramuscular Mapk Signaling Following High Volume And High Intensity Resistance Exercise Protocols In Trained Men

Keywords

Anabolic intramuscular signaling; ERK; JNK; Mitogen-activated protein kinase; p38

Abstract

Purpose: To examine the mitogen-activated protein kinase (MAPK) family of signaling proteins following typical high volume (HV) and high intensity (HI) lower body resistance exercise protocols in resistance-trained men. Methods: Ten resistance-trained men (24.7 ± 3.4 year; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) performed each resistance exercise protocol in a random, counterbalanced order. The HV protocol utilized a load of 70 % 1-RM for sets of 10–12 repetitions with a 1-min rest period length between sets and exercises. The HI protocol utilized a load of 90 % 1-RM for sets of 3–5 repetitions with a 3-min rest period length between sets and exercises. Both protocols included six sets of barbell back squats and four sets of bilateral leg press, bilateral hamstring curls, bilateral leg extensions, and seated calf raises. Fine needle muscle biopsies of the vastus lateralis were completed at baseline (BL) and 1-h post exercise (1H). Results: No significant differences over time were noted for phosphorylation of MEK1, ERK1/2, p38, MSK1, ATF2, p53, or c-Jun (p > 0.05). No significance between trial interactions was noted for phosphorylation of MAPK signaling proteins, including MEK1, ERK1/2, p38, JNK, MSK1, ATF2, STAT1, p53, c-Jun, or HSP27 (p > 0.05). However, significant time effects were observed for phosphorylation of JNK (p < 0.01), HSP27 (p < 0.01), and STAT1 (p = 0.03). Phosphorylation of JNK, HSP27, and STAT1 was significantly elevated from BL at 1H for both HV and HI. Conclusions: HV and HI lower body resistance exercise protocols appear to elicit similar MAPK activation in resistance-trained men.

Publication Date

9-1-2016

Publication Title

European Journal of Applied Physiology

Volume

116

Issue

9

Number of Pages

1663-1670

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s00421-016-3417-8

Socpus ID

84975460293 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84975460293

This document is currently not available here.

Share

COinS