On-Chip Whole Blood Plasma Separator Based On Microfiltration, Sedimentation And Wetting Contrast

Abstract

Miniaturized on-chip blood separators have a great value for point-of-care diagnosis. In our work, a combined design strategy—microfiltration, sedimentation in a retarded flow, and wetting contrast—was taken to overcome the known limitations of on-chip blood separators. Our microfluidic chip consists of a polydimethylsiloxane micropillar array and an etched glass with microchannel branches. The red blood cells are significantly slowed and gradually settled down due to micropillars and enlarged dimension of a chamber. An etched glass microchannel allows the extraction of blood plasma exclusively due to the capillary effect. The fabricated microfluidic device can separate blood plasma from a whole blood sample without any external driving force or dilution. The measured plasma separation efficiency was close to 100 % from human whole blood. Autonomous on-chip separation and collection of blood plasma was demonstrated.

Publication Date

8-1-2016

Publication Title

Microsystem Technologies

Volume

22

Issue

8

Number of Pages

2077-2085

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s00542-015-2656-7

Socpus ID

84939636612 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84939636612

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