Synthesis And Antitubercular Activity Of 1,2,4-Trisubstitued Piperazines

Creator

Kyle H. Rohde, University of Central Florida
Heather A. Michaels, Torrey Pines Institute for Molecular Studies
Adel Nefzi, Torrey Pines Institute for Molecular Studies

Keywords

Antitubercular; Combinatorial chemistry; Solid phase synthesis; Substituted piperazines

Abstract

Parallel solid phase synthesis offers a unique opportunity for the synthesis and screening of large numbers of compounds and significantly enhances the prospect of finding new leads. We report the synthesis and antitubercular activity of chiral 1,2,4-trisubstituted piperazines derived from resin bound acylated dipeptides against Mycobacterium tuberculosis strain H37Rv.

Publication Date

5-1-2016

Publication Title

Bioorganic and Medicinal Chemistry Letters

Volume

26

Issue

9

Number of Pages

2206-2209

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.bmcl.2016.03.063

Copyright Status

Unknown

Socpus ID

84964039953 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84964039953

STARS Citation

Rohde, Kyle H.; Michaels, Heather A.; and Nefzi, Adel, "Synthesis And Antitubercular Activity Of 1,2,4-Trisubstitued Piperazines" (2016). Scopus Export 2015-2019. 2898.
https://stars.library.ucf.edu/scopus2015/2898