Hiv Capsid Assembly, Mechanism, And Structure

Abstract

The HIV genome materials are encaged by a proteinaceous shell called the capsid, constructed from 1000-1500 copies of the capsid proteins. Because its stability and integrity are critical to the normal life cycle and infectivity of the virus, the HIV capsid is a promising antiviral drug target. In this paper, we review the studies shaping our understanding of the structure and dynamics of the capsid proteins and various forms of their assemblies, as well as the assembly mechanism.

Publication Date

5-10-2016

Publication Title

Biochemistry

Volume

55

Issue

18

Number of Pages

2539-2552

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/acs.biochem.6b00159

Socpus ID

84969651429 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84969651429

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