Hybrid Cavity-Coupled Plasmonic Biosensors For Low Concentration, Label-Free And Selective Biomolecular Detection

Abstract

Simple optical techniques that can accurately and selectively identify organic and inorganic material in a reproducible manner are of paramount importance in biological sensing applications. In this work, we demonstrate that a nanoimprinted plasmonic pattern with locked-in dimensions supports sharp deterministic hybrid resonances when coupled with an optical cavity suitable for high sensitive surface detection. The surface sensing property of this hybrid system is quantified by precise atomic layer growth of aluminum oxide using the atomic layer deposition technique. The analyte specific sensing ability is demonstrated in the detection of two dissimilar analytes, inorganic amine-coated iron oxide nanoparticles and organic streptavidin protein. Femto to nanomolar detection limits were achieved with the proposed coupled plasmonic system based on the versatile and robust soft nanoimprinting technique, which promises practical low cost biosensors.

Publication Date

10-31-2016

Publication Title

Optics Express

Volume

24

Issue

22

Number of Pages

25785-25796

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1364/OE.24.025785

Socpus ID

84994689550 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84994689550

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