A Fast Method For Bisphenol A And Six Analogues (S, F, Z, P, Af, Ap) Determination In Urine Samples Based On Dispersive Liquid-Liquid Microextraction And Liquid Chromatography-Tandem Mass Spectrometry
Keywords
Biomonitoring; Bisphenol A; Dispersive liquid-liquid microextraction; Fast method; Liquid chromatography-tandem mass spectrometry; Urine
Abstract
In this study, a novel method combining dispersive liquid-liquid microextraction (DLLME) and fast liquid chromatography coupled to mass spectrometry (LC-MS/MS) was developed and validated for the extraction and determination of bisphenol A (BPA) and six bisphenol analogues, namely bisphenol S (BPS), bisphenol F (BPF), bisphenol P (BPP), bisphenol Z (BPZ), bisphenol AP (BPAP) and bisphenol AF (BPAF) in human urine samples. Type and volume of extraction and disperser solvents, pH sample, ionic strength, and agitation were evaluated. The matrix-matched calibration curves of all analytes were linear with correlation coefficients higher than 0.99 in the range level of 0.5-20.0 ng mL-1. The relative standard deviation (RSD), precision, at three concentrations (1.0, 8.0 and 15.0 ng mL-1) was lower than 15% with accuracy ranging from 90 to 112%. The biomonitoring capability of the new method was confirmed with the analysis of 50 human urine samples randomly collected from Brazilians. BPA was detected in 92% of the analyzed samples at concentrations ranging
Publication Date
7-1-2016
Publication Title
Talanta
Volume
154
Number of Pages
511-519
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1016/j.talanta.2016.03.098
Copyright Status
Unknown
Socpus ID
84963673072 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84963673072
STARS Citation
Rocha, Bruno Alves; Da Costa, Bruno Ruiz Brandão; De Albuquerque, Nayara Cristina Perez; De Oliveira, Anderson Rodrigo Moraes; and Souza, Juliana Maria Oliveira, "A Fast Method For Bisphenol A And Six Analogues (S, F, Z, P, Af, Ap) Determination In Urine Samples Based On Dispersive Liquid-Liquid Microextraction And Liquid Chromatography-Tandem Mass Spectrometry" (2016). Scopus Export 2015-2019. 3341.
https://stars.library.ucf.edu/scopus2015/3341