A Fast Method For Bisphenol A And Six Analogues (S, F, Z, P, Af, Ap) Determination In Urine Samples Based On Dispersive Liquid-Liquid Microextraction And Liquid Chromatography-Tandem Mass Spectrometry

Keywords

Biomonitoring; Bisphenol A; Dispersive liquid-liquid microextraction; Fast method; Liquid chromatography-tandem mass spectrometry; Urine

Abstract

In this study, a novel method combining dispersive liquid-liquid microextraction (DLLME) and fast liquid chromatography coupled to mass spectrometry (LC-MS/MS) was developed and validated for the extraction and determination of bisphenol A (BPA) and six bisphenol analogues, namely bisphenol S (BPS), bisphenol F (BPF), bisphenol P (BPP), bisphenol Z (BPZ), bisphenol AP (BPAP) and bisphenol AF (BPAF) in human urine samples. Type and volume of extraction and disperser solvents, pH sample, ionic strength, and agitation were evaluated. The matrix-matched calibration curves of all analytes were linear with correlation coefficients higher than 0.99 in the range level of 0.5-20.0 ng mL-1. The relative standard deviation (RSD), precision, at three concentrations (1.0, 8.0 and 15.0 ng mL-1) was lower than 15% with accuracy ranging from 90 to 112%. The biomonitoring capability of the new method was confirmed with the analysis of 50 human urine samples randomly collected from Brazilians. BPA was detected in 92% of the analyzed samples at concentrations ranging

Publication Date

7-1-2016

Publication Title

Talanta

Volume

154

Number of Pages

511-519

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.talanta.2016.03.098

Socpus ID

84963673072 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84963673072

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