Title

Cognition Predicts Quality Of Life Among Patients With End-Stage Liver Disease

Keywords

cognitive functioning; hepatic encephalopathy; integrated care.; neuropsychological screening

Abstract

Background Impaired cognitive functioning and poor quality of life (QoL) are both common among patients with end-stage liver disease; however, it is unclear how these are related. Objective This study examines how specific cognitive domains predict QoL among liver transplant candidates by replicating Stewart and colleagues’ (2010) 3-factor model of cognitive functioning, and determining how variability in these cognitive domains predicts mental health and physical QoL. Methods The sample included 246 patients with end-stage liver disease who were candidates for liver transplant at a large, Midwestern health care center. Measures, including the Repeatable Battery for the Assessment of Neuropsychological Status, Trail Making Test, Shipley Institute of Living Scale, Short-Form Health Survey-36 Version 2, and Hospital Anxiety and Depression Scale, comprised latent variables representing global intellectual functioning, psychomotor speed, and learning and memory functioning. Results Confirmatory factor analysis results indicate that the 3-factor solution model comprised of global intellectual functioning, psychomotor speed, and learning and memory functioning fit the data well. Addition of physical and mental health QoL latent factors resulted in a structural model also with good fit. Results related physical QoL to global intellectual functioning, and mental health QoL to global intellectual functioning and psychomotor functioning. Conclusions Findings elucidate a relationship between cognition and QoL and support the use of routine neuropsychological screening with end-stage liver disease patients, specifically examining the cognitive domains of global intellectual, psychomotor, and learning and memory functioning. Subsequently, screening results may inform implementation of targeted interventions to improve QoL.

Publication Date

9-1-2016

Publication Title

Psychosomatics

Volume

57

Issue

5

Number of Pages

514-521

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.psym.2016.03.006

Socpus ID

84985991361 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84985991361

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