Fractal Analysis Reveals Subclasses Of Neurons And Suggests An Explanation Of Their Spontaneous Activity

Keywords

Detrended fluctuation analysis; Fractal scaling; Mitral cells; Olfactory bulb; Self-organized criticality; Spontaneous activity

Abstract

The present work used fractal time series analysis (detrended fluctuation analysis; DFA) to examine the spontaneous activity of single neurons in an anesthetized animal model, specifically, the mitral cells in the rat main olfactory bulb. DFA bolstered previous research in suggesting two subclasses of mitral cells. Although there was no difference in the fractal scaling of the interspike interval series at the shorter timescales, there was a significant difference at longer timescales. Neurons in Group B exhibited fractal, power-law scaled interspike intervals, whereas neurons in Group A exhibited random variation. These results raise questions about the role of these different cells within the olfactory bulb and potential explanations of their dynamics. Specifically, self-organized criticality has been proposed as an explanation of fractal scaling in many natural systems, including neural systems. However, this theory is based on certain assumptions that do not clearly hold in the case of spontaneous neural activity, which likely reflects intrinsic cell dynamics rather than activity driven by external stimulation. Moreover, it is unclear how self-organized criticality might account for the random dynamics observed in Group A, and how these random dynamics might serve some functional role when embedded in the typical activity of the olfactory bulb. These theoretical considerations provide direction for additional experimental work.

Publication Date

7-28-2016

Publication Title

Neuroscience Letters

Volume

626

Number of Pages

54-58

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.neulet.2016.05.017

Socpus ID

84969632457 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84969632457

This document is currently not available here.

Share

COinS