Nephro-Protective Action Of P. Santalinus Against Alcohol-Induced Biochemical Alterations And Oxidative Damage In Rats
Keywords
Alcohol; Nephro-toxicity; Oxidative stress/Nitrosative stress; P. santalinus
Abstract
The present study investigated the antioxidant potential of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced nephro-toxicity. The results indicated an increase in the concentration of kidney damage plasma markers, urea and creatinine with a concomitant decrease in the concentration of uric acid in alcohol-administered rats. A significant decrease in plasma electrolytes and mineral levels with increased kidney thiobarbituric acid reactive substances (TBARS) and nitric oxide (NOx) levels was also observed. PSE treatment to alcohol-administered rats effectively prevented the elevation in TBARS and NOx levels. Decreased activity of Na+/K+-ATPase in alcohol administered rats was brought to near normal levels with treatment of PSE. Chronic alcohol consumption affects antioxidant enzymatic activity and reabsorption function of the kidney which is evident from the decreased level of GSH as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione s-transferase (GST). However, treatment with PSE to alcohol-administered rats significantly enhanced these enzymatic activities and reduced glutathione (GSH) content close to normal level. Alcohol-induced organ damage was evident from morphological changes in the kidney. Nevertheless, administration of PSE effectively restored these morphological changes to normal. The flavonoid and tannoid compounds might have protective activity against alcohol-induced oxidative/nitrosative stress mediated kidney damage.
Publication Date
12-1-2016
Publication Title
Biomedicine and Pharmacotherapy
Volume
84
Number of Pages
740-746
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1016/j.biopha.2016.09.103
Copyright Status
Unknown
Socpus ID
84989332414 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84989332414
STARS Citation
Bulle, Saradamma; Reddy, Vaddi Damodara; Hebbani, Ananda Vardhan; Padmavathi, Pannuru; and Challa, Chandrasekhar, "Nephro-Protective Action Of P. Santalinus Against Alcohol-Induced Biochemical Alterations And Oxidative Damage In Rats" (2016). Scopus Export 2015-2019. 3565.
https://stars.library.ucf.edu/scopus2015/3565