Title

Nephro-Protective Action Of P. Santalinus Against Alcohol-Induced Biochemical Alterations And Oxidative Damage In Rats

Keywords

Alcohol; Nephro-toxicity; Oxidative stress/Nitrosative stress; P. santalinus

Abstract

The present study investigated the antioxidant potential of P. santalinus heartwood methanolic extract (PSE) against alcohol-induced nephro-toxicity. The results indicated an increase in the concentration of kidney damage plasma markers, urea and creatinine with a concomitant decrease in the concentration of uric acid in alcohol-administered rats. A significant decrease in plasma electrolytes and mineral levels with increased kidney thiobarbituric acid reactive substances (TBARS) and nitric oxide (NOx) levels was also observed. PSE treatment to alcohol-administered rats effectively prevented the elevation in TBARS and NOx levels. Decreased activity of Na+/K+-ATPase in alcohol administered rats was brought to near normal levels with treatment of PSE. Chronic alcohol consumption affects antioxidant enzymatic activity and reabsorption function of the kidney which is evident from the decreased level of GSH as well as the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione s-transferase (GST). However, treatment with PSE to alcohol-administered rats significantly enhanced these enzymatic activities and reduced glutathione (GSH) content close to normal level. Alcohol-induced organ damage was evident from morphological changes in the kidney. Nevertheless, administration of PSE effectively restored these morphological changes to normal. The flavonoid and tannoid compounds might have protective activity against alcohol-induced oxidative/nitrosative stress mediated kidney damage.

Publication Date

12-1-2016

Publication Title

Biomedicine and Pharmacotherapy

Volume

84

Number of Pages

740-746

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.biopha.2016.09.103

Socpus ID

84989332414 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84989332414

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