Safety And Efficacy Of Vismodegib In Patients Aged ≥65 Years With Advanced Basal Cell Carcinoma

Keywords

Age; Basal cell carcinoma; Hedgehog pathway inhibitor; Locally advanced basal cell carcinoma; Vismodegib

Abstract

Because many patients with unresectable basal cell carcinoma (BCC) are aged ≥65 years, this study explores the efficacy and safety of vismodegib in these patients with locally advanced (la) or metastatic (m) basal cell carcinoma (BCC) in the ERIVANCE BCC trial and the expanded access study (EAS).We compared patients aged ≥65 years to patients aged < 65 years taking vismodegib 150 mg/day, using descriptive statistics for response and safety. Patients aged ≥65 years (laBCC/mBCC) were enrolled in ERIVANCE BCC (33/14) and EAS (27/26). Investigator-assessed best overall response rate in patients ≥65 and < 65 years was 46.7%/35.7% and 72.7%/52.6% (laBCC/mBCC), respectively, in ERIVANCE BCC and 45.8%/33.3% and 46.9%/28.6%, respectively, in EAS. These differences were not clinically meaningful. Safety was similar in both groups, although those aged ≥65 years had a higher percentage of grade 3-5 adverse events than those aged < 65 years. Vismodegib demonstrated similar clinical activity and adverse events regardless of age.

Publication Date

1-1-2016

Publication Title

Oncotarget

Volume

7

Issue

46

Number of Pages

76118-76124

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.18632/oncotarget.12660

Socpus ID

84996993024 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84996993024

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