Temporal Profile Of Early Pulmonary Hypertension In Preterm Infants

Keywords

BPD; neonatal transition; preterm infants; pulmonary hypertension

Abstract

Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography every 7 to 10 days until 36 weeks postmenstrual age. Results Groups with and without early PH were comparable except for higher Fio 2 by day 10 among infants with early PH. Early PH was moderate in extent and resolved in all infants with recurrence in one infant. Among infants without early PH, five infants developed late PH. In both groups, development of late PH occurred in association with important neonatal morbidities, such as patent ductus arteriosus, bronchopulmonary dysplasia, and infection. Conclusion Early moderate PH among preterm infants resolves over a variable time period but recurrence is possible. Late PH can appear during the course of hospitalization in association with other clinical morbidities.

Publication Date

7-1-2016

Publication Title

American Journal of Perinatology

Volume

33

Issue

9

Number of Pages

903-909

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1055/s-0036-1581079

Socpus ID

84963552974 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84963552974

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