Evaluation Of A Bilayered, Micropatterned Hydrogel Dressing For Full-Thickness Wound Healing

Keywords

biomaterials; gelatin; hydrogel; microarchitecture; Micropattern; wound healing

Abstract

Nearly 12 million wounds are treated in emergency departments throughout the United States every year. The limitations of current treatments for complex, full-thickness wounds are the driving force for the development of new wound treatment devices that result in faster healing of both dermal and epidermal tissue. Here, a bilayered, biodegradable hydrogel dressing that uses microarchitecture to guide two key steps in the proliferative phase of wound healing, re-epithelialization, and revascularization, was evaluated in vitro in a cell migration assay and in vivo in a bipedicle ischemic rat wound model. Results indicate that the Sharklet™-micropatterned apical layer of the dressing increased artificial wound coverage by up to 64%, P = 0.024 in vitro. In vivo evaluation demonstrated that the bilayered dressing construction enhanced overall healing outcomes significantly compared to untreated wounds and that these outcomes were not significantly different from a leading clinically available wound dressing. Collectively, these results demonstrate high potential for this new dressing to effectively accelerate wound healing.

Publication Date

5-1-2016

Publication Title

Experimental Biology and Medicine

Volume

241

Issue

9

Number of Pages

986-995

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1177/1535370216640943

Socpus ID

84971655074 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84971655074

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