Preventing Bacterial Growth On Implanted Device With An Interfacial Metallic Film And Penetrating X-Rays

Abstract

Device-related infections have been a big problem for a long time. This paper describes a new method to inhibit bacterial growth on implanted device with tissue-penetrating X-ray radiation, where a thin metallic film deposited on the device is used as a radio-sensitizing film for bacterial inhibition. At a given dose of X-ray, the bacterial viability decreases as the thickness of metal film (bismuth) increases. The bacterial viability decreases with X-ray dose increases. At X-ray dose of 2.5 Gy, 98 % of bacteria on 10 nm thick bismuth film are killed; while it is only 25 % of bacteria are killed on the bare petri dish. The same dose of X-ray kills 8 % fibroblast cells that are within a short distance from bismuth film (4 mm). These results suggest that penetrating X-rays can kill bacteria on bismuth thin film deposited on surface of implant device efficiently.

Publication Date

2-1-2015

Publication Title

Journal of Materials Science: Materials in Medicine

Volume

26

Issue

2

Number of Pages

1-6

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s10856-014-5374-2

Socpus ID

84922207184 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84922207184

This document is currently not available here.

Share

COinS