Current And Investigational Drugs For The Treatment Of Diabetic Retinopathy

Keywords

Diabetes; diabetic retinopathy; drug development; integrins; macular edema; retinal neovascularization; VEGF

Abstract

Introduction: Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the two complications of diabetes that cause visual loss and blindness. Laser photo-coagulation in the past was used to prevent progression of disease to these advanced stages. Advances in pathophysiologic understanding of DME and PDR have ushered the development of effective targeted therapy that given intravitreally improves vision and prevents blindness. While effective, these therapies require frequent administration and are not universally effective. Areas covered: This purpose of this paper is to review the current pathophysiologic understanding and treatments for DME and PDR as well as the novel treatments currently being developed. The treatments will be juxtaposed to the factor in the disease cascade being targeted. The potential role of these novel treatment in the clinical armamentarium are postulated. Expert opinion: Mono-therapy, single category targeting is the current strategy being utilized clinically. However, diabetic retinopathy needs combination therapy. Therapies that will prove successful will address multiple factors involved in the pathogenesis of diabetic retinopathy.

Publication Date

9-1-2016

Publication Title

Expert Opinion on Investigational Drugs

Volume

25

Issue

9

Number of Pages

1011-1022

Document Type

Editorial Material

Personal Identifier

scopus

DOI Link

https://doi.org/10.1080/13543784.2016.1201062

Socpus ID

84983268757 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84983268757

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