Cancer Stem Cells And Chemoresistance: The Smartest Survives The Raid

Keywords

Cancer stem cell; Chemoresistance; Chemotherapy; Targeted therapy

Abstract

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell (CSC) behind the mechanisms for this deadly disease. This review briefly introduces the basics of the conventional chemotherapies, updates the CSC theories, highlights the molecular and cellular mechanisms by which CSC smartly designs and utilizes multiple lines of self-defense to avoid being killed by chemotherapy, and concisely summarizes recent progress in studies on CSC-targeted therapies in the end, with the hope to help guide future research toward developing more effective therapeutic strategies to eradicate tumor cells in the patients.

Publication Date

4-1-2016

Publication Title

Pharmacology and Therapeutics

Volume

160

Number of Pages

145-158

Document Type

Editorial Material

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.pharmthera.2016.02.008

Socpus ID

84959144672 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84959144672

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