2D And 3D Mechanobiology In Human And Nonhuman Systems

Keywords

biofilms; biomechanics; developmental biology; fluid flow; mammalian cells; stretch

Abstract

Mechanobiology involves the investigation of mechanical forces and their effect on the development, physiology, and pathology of biological systems. The human body has garnered much attention from many groups in the field, as mechanical forces have been shown to influence almost all aspects of human life ranging from breathing to cancer metastasis. Beyond being influential in human systems, mechanical forces have also been shown to impact nonhuman systems such as algae and zebrafish. Studies of nonhuman and human systems at the cellular level have primarily been done in two-dimensional (2D) environments, but most of these systems reside in three-dimensional (3D) environments. Furthermore, outcomes obtained from 3D studies are often quite different than those from 2D studies. We present here an overview of a select group of human and nonhuman systems in 2D and 3D environments. We also highlight mechanobiological approaches and their respective implications for human and nonhuman physiology.

Publication Date

8-31-2016

Publication Title

ACS Applied Materials and Interfaces

Volume

8

Issue

34

Number of Pages

21869-21882

Document Type

Editorial Material

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/acsami.5b12064

Socpus ID

84984924834 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84984924834

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