Modeling Barrier Tissues In Vitro: Methods, Achievements, And Challenges

Keywords

Barrier tissues; Drug discovery; In vitro modeling; Microfluidic technologies; Microphysiological systems; Organ-on-a-chip

Abstract

Organ-on-a-chip devices have gained attention in the field of in vitro modeling due to their superior ability in recapitulating tissue environments compared to traditional multiwell methods. These constructed growth environments support tissue differentiation and mimic tissue-tissue, tissue-liquid, and tissue-air interfaces in a variety of conditions. By closely simulating the in vivo biochemical and biomechanical environment, it is possible to study human physiology in an organ-specific context and create more accurate models of healthy and diseased tissues, allowing for observations in disease progression and treatment. These chip devices have the ability to help direct, and perhaps in the distant future even replace animal-based drug efficacy and toxicity studies, which have questionable relevance to human physiology. Here, we review recent developments in the in vitro modeling of barrier tissue interfaces with a focus on the use of novel and complex microfluidic device platforms.

Publication Date

3-1-2016

Publication Title

EBioMedicine

Volume

5

Number of Pages

30-39

Document Type

Editorial Material

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.ebiom.2016.02.023

Socpus ID

84958568431 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84958568431

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