Atherosclerosis - Do We Know Enough Already To Prevent It?

Abstract

In this review, we have briefly summarized the characteristics of lipids and lipoproteins and the atherosclerotic process. The development of atherosclerosis is a continuous process that involves numerous cellular and acellular processes that influence the behavior of each other. These include oxidative stress, lipoprotein modifications, macrophage polarization, macrophage lipid accumulation, generation of pro- and anti-inflammatory components, calcification, cellular growth and proliferation, and plaque rupture. The precise role(s) of many of these are unknown. Understanding the events at each particular stage might shed more light onto the process as a whole and could potentially reveal targets for intervention. Therapeutic modalities that work at one stage may have little to no influence on other stages of the disease.

Publication Date

4-1-2016

Publication Title

Current Opinion in Pharmacology

Volume

27

Number of Pages

92-102

Document Type

Editorial Material

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.coph.2016.02.006

Socpus ID

84960376528 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84960376528

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