Emerging Role For Regulated In Development And Dna Damage 1 (Redd1) In The Regulation Of Skeletal Muscle Metabolism

Keywords

DDIT4; Dig2; Muscle mass; RTP801

Abstract

Since its discovery, the protein regulated in development and DNA damage 1 (REDD1) has been implicated in the cellular response to various stressors. Most notably, its role as a repressor of signaling through the central metabolic regulator, the mechanistic target of rapamycin in complex 1 (mTORC1) has gained considerable attention. Not surprisingly, changes in REDD1 mRNA and protein have been observed in skeletal muscle under various physiological conditions (e.g., nutrient consumption and resistance exercise) and pathological conditions (e.g., sepsis, alcoholism, diabetes, obesity) suggesting a role for REDD1 in regulating mTORC1-dependent skeletal muscle protein metabolism. Our understanding of the causative role of REDD1 in skeletal muscle metabolism is increasing mostly due to the availability of genetically modified mice in which the REDD1 gene is disrupted. Results from such studies provide support for an important role for REDD1 in the regulation of mTORC1 as well as reveal unexplored functions of this protein in relation to other aspects of skeletal muscle metabolism. The goal of this work is to provide a comprehensive review of the role of REDD1 (and its paralog REDD2) in skeletal muscle during both physiological and pathological conditions.

Publication Date

7-1-2016

Publication Title

American Journal of Physiology - Endocrinology and Metabolism

Volume

311

Issue

1

Number of Pages

E157-E174

Document Type

Editorial Material

Personal Identifier

scopus

DOI Link

https://doi.org/10.1152/ajpendo.00059.2016

Socpus ID

84983760426 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84983760426

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