Title

Nitration Of Hsp90 On Tyrosine 33 Regulates Mitochondrial Metabolism

Abstract

Background: Heat shock protein 90 (Hsp90) is a pro-survival molecular chaperone that is nitrated only in pathological conditions. Results: Hsp90 nitrated on tyrosine 33 down-regulates mitochondrial activity. Conclusion: Differential nitration states of Hsp90 regulate distinct aspects of cellular metabolism. Significance: This is the first demonstration of a site-specific-nitrated protein regulating mitochondrial metabolism.

Publication Date

7-31-2015

Publication Title

Journal of Biological Chemistry

Volume

290

Issue

31

Number of Pages

19055-19066

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1074/jbc.M115.663278

Socpus ID

84940558811 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84940558811

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