Title

Dragmacidin G, A Bioactive Bis-Indole Alkaloid From A Deep-Water Sponge Of The Genus Spongosorites

Keywords

Antibacterial; Bis(indole) alkaloid; Pancreatic cancer; Spongosorites

Abstract

A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.

Publication Date

1-1-2017

Publication Title

Marine Drugs

Volume

15

Issue

1

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.3390/md15010016

Socpus ID

85012902563 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85012902563

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