Real-Time Intraoperative Monitoring Of Blood Coagulability Via Coherence-Gated Light Scattering

Abstract

When characterizing dynamic processes, ergodicity - that is, the equivalence of time averages and of averages over a system's possible microstates - is often invoked. Yet many complex social, economic and material systems are such that practical observations cannot survey the entire ensemble of microstates. In the case of non-ergodic fluids, their slow structural dynamics makes such an approach prohibitive. Blood is a prominent example of a non-ergodic, complex fluid for which today's standards for coagulation tests in vivo are chemically induced offline assays. Here, we show that heterodyne amplification - that is, amplification of a signal by frequency conversion - combined with suitable control of spatiotemporal coherence permits measurements of non-stationary dynamics in non-ergodic, complex media. By taking advantage of this approach, we developed an optical-fibre-based tool that can be directly incorporated into standard vascular-access devices for real-time monitoring of blood coagulability in the operating room.

Publication Date

2-10-2017

Publication Title

Nature Biomedical Engineering

Volume

1

Issue

2

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1038/s41551-017-0028

Socpus ID

85029876968 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85029876968

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