The Role Of Androgens In The Regulation Of Muscle Oxidative Capacity Following Aerobic Exercise Training

Keywords

Autophagy; BNIP3; Mitochondria dysfunction; Mitophagy; Testosterone

Abstract

Reduced production or bioavailability of androgens, termed hypogonadism, occurs in a variety of pathological conditions. While androgens target numerous tissues throughout the body, hypogonadism specifically reduces the ability of skeletal muscle to produce adenosine triphosphate aerobically, i.e., muscle oxidative capacity. This has important implications for overall health as muscle oxidative capacity impacts a number of metabolic processes. Although androgen replacement therapy is effective at restoring muscle oxidative capacity in hypogonadal individuals, this is not a viable therapeutic option for all who are experiencing hypogonadism. While aerobic exercise may be a viable alternative to increase muscle oxidative capacity, it is unknown whether androgen depletion affects this adaptation. To determine this, sham and castrated mice were randomized to remain sedentary or undergo 8 weeks of aerobic treadmill exercise training. All mice were fasted overnight prior to sacrifice. Though exercise increased markers of muscle oxidative capacity independent of castration (cytochrome c oxidase subunit IV and cytochrome c), these measures were lower in castrated mice. This reduction was not due to a difference in peroxisome proliferator activated receptor gamma coactivator 1 alpha protein content, as expression was increased to a similar absolute value in sham and castrated animals following exercise training. However, markers of BCL2/Adenovirus E1B 19 kDa Interacting Protein 3 (BNIP3)-mediated mitophagy were increased by castration independent of exercise. Together, these data show that exercise training can increase markers of muscle oxidative capacity following androgen depletion. However, these values are reduced by androgen depletion likely due in part to elevated BNIP3-mediated mitophagy.

Publication Date

1-1-2017

Publication Title

Applied Physiology, Nutrition and Metabolism

Volume

42

Issue

9

Number of Pages

1001-1007

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1139/apnm-2017-0230

Socpus ID

85030718208 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85030718208

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