Multi-Scale Pulsatile Cfd Modeling Of Thrombus Transport In A Patient-Specific Lvad Implantation

Keywords

LVAD; Multi-scale CFD; Stroke; Thrombus transport

Abstract

Purpose: Predictive models implemented in medical procedures can potentially bring great benefit to patients and represent a step forward in targeted treatments based on a patient's physiological condition. It is the purpose of this paper to outline such a model. Design/methodology/approach: A multi-scale 0D-3D model based on patient specific geometry combines a 0-dimensional lumped parameter model (LPM) with a 3D computational fluid dynamics (CFD) analysis coupled in time, to obtain physiologically viable flow parameters. Findings: A comparison of physiological data gathered from literature with flow-field measurements in this model shows the viability of this method in relation to potential predictions of pathological flows repercussions and candidate treatments. Research limitations/implications: A limitation of the model is the absence of compliance in the walls in the CFD fluid domain; however, compliance of the peripheral vasculature is accounted for by the LPM. Currently, an attempt is in progress to extend this multi-scale model to account for the fluid-structure interaction of the ventricular assist device vasculature and hemodynamics. Originality/value: This work reports on a predictive pulsatile flow model that can be used to investigate surgical alternatives to reduce strokes in LVADs.

Publication Date

1-1-2017

Publication Title

International Journal of Numerical Methods for Heat and Fluid Flow

Volume

27

Issue

5

Number of Pages

1022-1039

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1108/HFF-10-2016-0378

Socpus ID

85026672782 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85026672782

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