A Fast Ultrasound-Assisted Extraction Sample Preparation For Multi-Elemental Determination Of Contaminants In Pharmaceutical Ingredients By Icp-Ms

Abstract

There is a great demand for the development of simple, highly sensitive and selective methods for elemental analysis of active pharmaceutical ingredients (API)-According to the United States Pharmacopeia (USP), the presence of some elements in pharmaceutical ingredients should be monitored routinely. The present study addresses an important issue for the elemental analysis of active pharmaceutical ingredients (API), which is sample preparation. Ultrasoundassisted extraction (UAE) was evaluated for the purpose at hand with the aid of inductively coupled plasma mass spectrometry with quadrupole (q-ICP-MS) and dynamic reaction cell (DRC-ICP-MS). The limits of detection varied from 0.001 ng g-1 (103Rh) to 0.083 ng g-1 (75As). Validation of the proposed procedure was achieved by performing recovery experiments and by comparing the results obtained for the analysis of seven commercial products using the proposed procedure with those obtained by using microwave-assisted digestion (MAD). In addition, the determined values in commercial samples did not exceed the concentration limits for oral drug products (drug substances and excipients) established by the USP Chapter <232>.

Publication Date

11-1-2017

Publication Title

Atomic Spectroscopy

Volume

38

Issue

6

Number of Pages

165-173

Document Type

Article

Personal Identifier

scopus

Socpus ID

85041417367 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85041417367

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