Self-Assembling Molecular Logic Gates Based On Dna Crossover Tiles

Keywords

crossover tile; DNA computation; DNA nanotechnology; molecular beacon probe; molecular logic gates

Abstract

DNA-based computational hardware has attracted ever-growing attention due to its potential to be useful in the analysis of complex mixtures of biological markers. Here we report the design of self-assembling logic gates that recognize DNA inputs and assemble into crossover tiles when the output signal is high; the crossover structures disassemble to form separate DNA stands when the output is low. The output signal can be conveniently detected by fluorescence using a molecular beacon probe as a reporter. AND, NOT, and OR logic gates were designed. We demonstrate that the gates can connect to each other to produce other logic functions.

Publication Date

7-5-2017

Publication Title

ChemPhysChem

Volume

18

Issue

13

Number of Pages

1730-1734

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/cphc.201700109

Socpus ID

85016252825 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85016252825

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