Ovarian Aging And The Activation Of The Primordial Follicle Reserve In The Long-Lived Ames Dwarf And The Short-Lived Bgh Transgenic Mice

Keywords

FOXO; GH; IGF; Ovarian aging; Ovarian follicular reserve; Primordial follicle

Abstract

The aim of this study was to evaluate the effect of growth hormone (GH) in the maintenance of the ovarian primordial follicle reserve. Ovaries from 16 mo old GH-deficient Ames Dwarf (df/df) and Normal (N/df) mice were used. A subgroup of df/df and N mice received GH or saline injections for six weeks starting at 14 mo of age. In addition, ovaries from 12 mo old mice overexpressing bovine GH (bGH) and controls were used. df/df mice had higher number of primordial and total follicles than N/df mice (p < 0.05), while GH treatment decreased follicle counts in both genotypes (p < 0.05). In addition, bGH mice had lower number of primordial and total follicles than the controls (p < 0.05). pFoxO3a levels were higher in mice treated with GH and in bGH mice (p < 0.05) when comparing with age match controls. These results indicate that increased circulating GH is associated with a reduced ovarian primordial follicle reserve and increased pFoxO3a content in oocytes.

Publication Date

11-5-2017

Publication Title

Molecular and Cellular Endocrinology

Volume

455

Number of Pages

23-32

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.mce.2016.10.015

Socpus ID

85001574822 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85001574822

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