In Vitro Photodynamic Studies Of A Bodipy-Based Photosensitizer

Keywords

BODIPY; Boron; Dyes/Pigments; Photodynamic therapy; Photosensitizer; Singlet oxygen

Abstract

A new halogenated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivative was designed as a singlet-oxygen photosensitizer (PS) for use as a photodynamic therapy (PDT) agent, and its photophysical properties were characterized. The PS, having two iodine atom substituents, exhibited a low fluorescence quantum yield (ΦFL) of 0.02 and high singlet-oxygen-generation quantum yield (ΦΔ) of 0.93. Furthermore, in vitro photodynamic activities were evaluated to assess the potential of using the PS for PDT. A propidium iodide (PI) fluorescence assay and live-cell imaging of Lewis lung carcinoma (LLC) cells demonstrated that the cellular damage is induced by the photosensitization of the BODIPY dye, which subsequently leads to cell death by necrosis.q.

Publication Date

1-3-2017

Publication Title

European Journal of Organic Chemistry

Volume

2017

Issue

1

Number of Pages

25-28

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/ejoc.201601054

Socpus ID

85007276061 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85007276061

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