Motuporamine Derivatives As Antimicrobial Agents And Antibiotic Enhancers Against Resistant Gram-Negative Bacteria

Keywords

antibiotics; antimicrobial agents; bacterial resistance; membranes; motuporamine; polyamine derivatives

Abstract

Dihydromotuporamine C and its derivatives were evaluated for their in vitro antimicrobial activities and antibiotic enhancement properties against Gram-negative bacteria and clinical isolates. The mechanism of action of one of these derivatives, MOTU-N44, was investigated against Enterobacter aerogenes by using fluorescent dyes to evaluate outer-membrane depolarization and permeabilization. Its efficiency correlated with inhibition of dye transport, thus suggesting that these molecules inhibit drug transporters by de-energization of the efflux pump rather than by direct interaction of the molecule with the pump. This suggests that depowering the efflux pump provides another strategy to address antibiotic resistance.

Publication Date

2-1-2017

Publication Title

ChemBioChem

Volume

18

Issue

3

Number of Pages

276-283

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/cbic.201600532

Socpus ID

85010297180 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85010297180

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