Ovarian Transcriptome Associated With Reproductive Senescence In The Long-Living Ames Dwarf Mice

Keywords

GH; IGF; mRNA; Ovarian aging; Transcriptome

Abstract

The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses.

Publication Date

1-5-2017

Publication Title

Molecular and Cellular Endocrinology

Volume

439

Number of Pages

328-336

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.mce.2016.09.019

Socpus ID

85027948181 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85027948181

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