Title

Intracerebral Haemorrhage-Induced Injury Progression Assessed By Cross-Sectional Photoacoustic Tomography

Abstract

In this study, we in vivo examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using cross-sectional photoacoustic tomography (csPAT). csPAT displayed high resolution with high sensitivity for ICH detection. The PAT images obtained showed high correlation with conventional histologic images. Quantitative analysis of the hematoma areas detected by csPAT showed high consistency with the neurologic deficit score (NDS). By utilizing the dual-wavelength method, the development of the hemoglobin area was monitored. Our results indicated that noninvasive csPAT can be used to track the dynamic progression of post-ICH, and to evaluate therapeutic interventions in preclinical ICH models.

Publication Date

12-1-2017

Publication Title

Biomedical Optics Express

Volume

8

Issue

12

Number of Pages

5814-5824

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1364/BOE.8.005814

Socpus ID

85037358648 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85037358648

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