Intracerebral Haemorrhage-Induced Injury Progression Assessed By Cross-Sectional Photoacoustic Tomography
Abstract
In this study, we in vivo examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using cross-sectional photoacoustic tomography (csPAT). csPAT displayed high resolution with high sensitivity for ICH detection. The PAT images obtained showed high correlation with conventional histologic images. Quantitative analysis of the hematoma areas detected by csPAT showed high consistency with the neurologic deficit score (NDS). By utilizing the dual-wavelength method, the development of the hemoglobin area was monitored. Our results indicated that noninvasive csPAT can be used to track the dynamic progression of post-ICH, and to evaluate therapeutic interventions in preclinical ICH models.
Publication Date
12-1-2017
Publication Title
Biomedical Optics Express
Volume
8
Issue
12
Number of Pages
5814-5824
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1364/BOE.8.005814
Copyright Status
Unknown
Socpus ID
85037358648 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/85037358648
STARS Citation
Yang, Jinge; Wu, Dan; Zhang, Guang; Zhao, Yuan; and Jiang, Max, "Intracerebral Haemorrhage-Induced Injury Progression Assessed By Cross-Sectional Photoacoustic Tomography" (2017). Scopus Export 2015-2019. 6024.
https://stars.library.ucf.edu/scopus2015/6024