The Alternate Effects Of Anti-Tnfα Therapeutics And Their Role In Mycobacterial Granulomatous Infection In Crohn’S Disease

Keywords

Anti-TNFα; Crohn’s disease; cytokines; granuloma; MAP; mycobacterium paratuberculosis; RHB-104; TNFα

Abstract

Introduction: Crohn’s disease is an inflammatory bowel disease that has been debated to be associated with bacterial triggers such as Mycobacterium avium subspecies paratuberculosis (MAP). Standard treatment of Crohn’s disease (CD) patients includes a family of immunomodulators and biologics such as Anti-Tumor Necrosis Factor alpha (Anti-TNFα). This cytokine in particular has been known to play vital roles in fighting microbial infections through formation and maintenance of granulomas. Areas covered: This perspective is focused on elucidating the negative effects of using Anti-TNFα therapeutic agents as a treatment option in CD patients who are more likely suspected to have MAP infection, and the role of other immunomodulators in MAP infection. Expert commentary: While treatment with Anti-TNFα is beneficial to reduce inflammation and to provide short term relief to the patients, it also compromises the immune system causing susceptibility to microbial infection. More than 50% of CD patients have shown no response to Anti-TNFα treatment which indicates a demand for introducing novel CD treatment in combination with antibiotics as a future CD treatment plan.

Publication Date

7-3-2017

Publication Title

Expert Review of Anti-Infective Therapy

Volume

15

Issue

7

Number of Pages

637-643

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1080/14787210.2017.1328276

Socpus ID

85019634411 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85019634411

This document is currently not available here.

Share

COinS