Regeneration Of Fat Cells From Myofibroblasts During Wound Healing

Abstract

Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro.Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.

Publication Date

2-17-2017

Publication Title

Science

Volume

355

Issue

6326

Number of Pages

748-752

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1126/science.aai8792

Socpus ID

85008709414 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85008709414

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