Outcomes Of Adjuvant Radiotherapy And Lymph Node Resection In Elderly Patients With Pancreatic Cancer Treated With Surgery And Chemotherapy

Keywords

Adjuvant radiation; Lymph node harvest; Outcomes in the elderly population; Pancreatic cancer

Abstract

Background: We sought to determine the effects of post-operative radiation therapy (PORT) and lymph node resection (LNR) on survival in patients ≥70 years with pancreatic cancer treated with surgery and chemotherapy. Methods: An analysis of patients ≥70 years with surgically resected pancreatic cancer who received chemotherapy from the SEER database between 2004-2008 was performed to determine association of PORT and LNR on survival. Results: We identified 961 patients who met inclusion criteria. There was a trend towards increased survival associated with PORT in all patients (P=0.052) and N1 patients (P=0.060) but no benefit in N0 patients (P=0.161). There was no difference in OS based on number of lymph nodes removed in all (P=0.741), N0 (P=0.588), and N1 (P=0.070) patients. MVA for all patients revealed that higher T stage, N1, and high grade tumors were prognostic for increased mortality, while there was decreased mortality with PORT and mild benefit with increased lymph nodes resected (P=0.084). Conclusions: PORT demonstrated no benefit in survival of pancreatic cancer patients ≥70 who are resected and treated with adjuvant chemotherapy. Future investigation will need to address age as a stratification factor for pancreatic cancer in the adjuvant setting.

Publication Date

10-1-2017

Publication Title

Journal of Gastrointestinal Oncology

Volume

8

Issue

5

Number of Pages

758-765

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.21037/jgo.2017.08.05

Socpus ID

85031692037 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85031692037

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