The Minimal Unit Of Infection: Mycobacterium Tuberculosis In The Macrophage

Keywords

Chemical Genetics; Environmental Cues; Intracellular Environment; Lipid utilization; Macrophage; Mycobacterium tuberculosis Infection; Phagocytosis; Reporter strains; Single-cell suspension

Abstract

Mycobacterium tuberculosis is the causative agent of human tuberculosis. The bacterium has the capacity to persist in its human host for decades prior to progressing to active disease. In fact, on balance, humans deal with M. tuberculosis infection quite effectively with only an estimated 5 to 10% of those infected actually ending up with clinical disease. However, because of the extraordinary penetrance of this infectious agent across the global population, this accounts for in excess of 1 million deaths due to tuberculosis every year. The combination with HIV in sub-Saharan Africa is catastrophic, and M. tuberculosis is now the leading cause of mortality among individuals living with HIV.

Publication Date

9-5-2017

Publication Title

Tuberculosis and the Tubercle Bacillus: Second Edition

Number of Pages

635-652

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1128/9781555819569.ch30

Socpus ID

85098190913 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85098190913

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