Alzheimer'S Disease - Current Status And Future Directions

Keywords

amyloid precursor protein; amyloid-beta plaques; apolipoprotein E; neurofibrillary tangles; neuroimaging; nutrition

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder of the brain. The presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), loss of neurons, synapses, and altered sensory perceptions, including memory loss, delineate AD. However, the cause of AD is not clearly known. Several genetic and nongenetic factors have been implicated in the disease. Of the genes, the 4 allele of apolipoprotein E is the largest known genetic risk factor of AD. This review article focuses on the various genetic and other predisposing factors that account for AD, pathophysiology of the disease, and the mechanisms by which Aβ plaques and NFTs are formed and could affect AD brain. In addition, recent advances and current diagnostics available for AD patients are detailed. As oxidative stress has been implicated in the etiology of the disease, special emphasis is given for nutrition based antioxidant therapies and interventional strategies for reducing/treating AD.

Publication Date

12-1-2017

Publication Title

Journal of Medicinal Food

Volume

20

Issue

12

Number of Pages

1141-1151

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1089/jmf.2017.0093

Socpus ID

85038405410 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85038405410

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