Self-Contained, Low-Cost Body-On-A-Chip Systems For Drug Development

Keywords

functional measurement; microphysiological systems; organ on a chip; organ–organ interactions; Pumpless; serum free

Abstract

Integrated multi-organ microphysiological systems are an evolving tool for preclinical evaluation of the potential toxicity and efficacy of drug candidates. Such systems, also known as Body-on-a-Chip devices, have a great potential to increase the successful conversion of drug candidates entering clinical trials into approved drugs. Systems, to be attractive for commercial adoption, need to be inexpensive, easy to operate, and give reproducible results. Further, the ability to measure functional responses, such as electrical activity, force generation, and barrier integrity of organ surrogates, enhances the ability to monitor response to drugs. The ability to operate a system for significant periods of time (up to 28 d) will provide potential to estimate chronic as well as acute responses of the human body. Here we review progress towards a self-contained low-cost microphysiological system with functional measurements of physiological responses. Impact statement: Multi-organ microphysiological systems are promising devices to improve the drug development process. The development of a pumpless system represents the ability to build multi-organ systems that are of low cost, high reliability, and self-contained. These features, coupled with the ability to measure electrical and mechanical response in addition to chemical or metabolic changes, provides an attractive system for incorporation into the drug development process. This will be the most complete review of the pumpless platform with recirculation yet written.

Publication Date

11-1-2017

Publication Title

Experimental Biology and Medicine

Volume

242

Issue

17

Number of Pages

1701-1713

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1177/1535370217694101

Socpus ID

85032341438 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85032341438

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