L-Arginine Modulates Glucose And Lipid Metabolism In Obesity And Diabetes

Keywords

Diabetes; Glucose/lipid metabolism; Insulin-resistance; L-arginine; Nitric oxide

Abstract

Type 2 diabetes has become a global public health problem affecting approximately 380 million people throughout the world. It can cause many complications and lead to greater mortality. At present, there is no available medicine for effectively preventing diabetes. L-arginine, a functional amino acid, the precursor of nitric oxide, plays a crucial role in maintenance, reproduction, growth anti-aging and immunity for animals. Growing clinical evidence indicates that dietary L-arginine supplementation can reduce obesity, decrease arterial blood pressure, resist oxidation and normalize endothelial dysfunction to bring about remission of type 2 diabetes. The potential molecular mechanism may play a role in modulating glucose homeostasis, promoting lipolysis, maintaining hormone levels ameliorating insulin resistance, and fetal programing in early stages. The possible signaling pathway of the beneficial effects of L-arginine likely involves L-arginine-nitric oxide pathway through which cell signal protein can be activated. Accumulating studies have indicated that L-arginine may have potential to prevent and/or relieve type 2 diabetes via restoring insulin sensitivity in vivo.

Publication Date

6-1-2017

Publication Title

Current Protein and Peptide Science

Volume

18

Issue

6

Number of Pages

599-608

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.2174/1389203717666160627074017

Socpus ID

85020936124 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85020936124

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