Permanent Cerebellar Degeneration After Acute Hyperthermia With Non-Toxic Lithium Levels: A Case Report And Review Of Literature

Keywords

Ataxia; Cerebellar degeneration; Cerebellum; Drug toxicity; Hyperthermia; Intoxication; Lithium; Lithium carbonate; Neuroleptics; Neurological sequel; Neurotoxicity; Serum levels; Therapeutic lithium

Abstract

This was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2 weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and longest follow-up case of chronic cerebellar syndrome after hyperthermia with non-toxic lithium levels.

Publication Date

12-1-2017

Publication Title

Cerebellum

Volume

16

Issue

5-6

Number of Pages

973-978

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s12311-017-0868-3

Socpus ID

85020291495 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85020291495

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