Monolithic Cmos-Based Neurotransmitter Detector For L024-Ch Simultaneous Recordings

Keywords

Amperometric sensors; Bioelectric phenomena; Biological cells; Biomedical transducers; Biosensors; Cell signaling; Electrochemical devices

Abstract

Neuroblastoma cells are regularly used to study Parkinson's disease, as they are suitable cell models. Specifically, the release of dopamine from neurssoblastoma cells is studied, as Parkinson's disease lowers the amount of dopamine released within the sustantia nigra, a structure within the midbrain that is important for controlling movement. To further the ability to study dopamine release from neuroblastoma cells, we developed a monolithic CMOS sensor array containing 1024 on-chip electrodes. Each electrode is 15 μm × 15 μm and is paired with a dedicated transimpedance amplifier capable of measuring sub-pA current. The channels throughout the array have both low-noise performance and spatiotemporal resolution enabling the study of dopamine release from a single vesicle. The presented device is used to record dopamine release from the SH-SY5Y neuroblastoma cell line to demonstrate its efficacy. The device's characteristics enable the study of the detailed molecular dynamics that occur during dopamine secretion.

Publication Date

12-20-2018

Publication Title

2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1109/BIOCAS.2018.8584681

Socpus ID

85060889213 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85060889213

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