High-Fat, High-Sugar Diet Induces Splenomegaly That Is Ameliorated With Exercise And Genistein Treatment

Keywords

Exercise; Genistein; High-fat diet; High-sugar diet; Spleen

Abstract

Objective: We tested the effect of exercise training and genistein treatment on splenomegaly in mice fed a high-fat, high-sugar diet (HFSD). Results: Male and female C57BL6 mice fed HFSD containing 60% fat along with drinking water containing 42 g/L sugar (55% sucrose/45% fructose) for 12 weeks exhibited significant obesity, hyperglycemia, and elevated plasma IL-6 levels. This was accompanied by splenomegaly characterized by spleen weights 50% larger than mice fed standard chow (P < 0.05) with enlarged rad and white pulps. Mice fed HFSD and treated with a combination of exercise (30 min/day, 5 days/week) and genistein (600 mg genistein/kg diet) had reduced spleen weight (P < 0.05). The decrease in spleen weight was associated with a significant improvement in red-to-white pulp area ratio and plasma glucose and IL-6 (P < 0.05). Our findings indicate that reversal of splenomegaly by regular exercise and genistein treatment may be important in the clinical management of HFSD-induced obesity.

Publication Date

10-22-2018

Publication Title

BMC Research Notes

Volume

11

Issue

1

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1186/s13104-018-3862-z

Socpus ID

85055153133 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85055153133

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