Title
An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure-Activity Relationship (Sar) Study At C2 Position
Abstract
An asymmetric synthesis of carbocyclic spiroindoline by sequential Michael reaction and [3 + 2]-cycloaddition is described. This protocol demonstrates excellent enantio- and diastereoselectivity with broad functional group tolerance. A diverse range of spiroindolines were prepared by this approach, and the products served as ideal substrates for C2 derivatization.
Publication Date
8-14-2015
Publication Title
Organic Letters
Volume
17
Issue
17
Number of Pages
4240-4243
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1021/acs.orglett.5b02031
Copyright Status
Unknown
Socpus ID
84940984560 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84940984560
STARS Citation
Zheng, Yongsheng; Cleaveland, Jacob; Richardson, David; and Yuan, Yu, "An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure-Activity Relationship (Sar) Study At C2 Position" (2015). Scopus Export 2015-2019. 841.
https://stars.library.ucf.edu/scopus2015/841