An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure-Activity Relationship (Sar) Study At C2 Position

Creator

Yongsheng Zheng, University of Central Florida
Jacob Cleaveland, University of Central Florida
David Richardson, University of Central Florida
Yu Yuan, University of Central Florida

Abstract

An asymmetric synthesis of carbocyclic spiroindoline by sequential Michael reaction and [3 + 2]-cycloaddition is described. This protocol demonstrates excellent enantio- and diastereoselectivity with broad functional group tolerance. A diverse range of spiroindolines were prepared by this approach, and the products served as ideal substrates for C2 derivatization.

Publication Date

8-14-2015

Publication Title

Organic Letters

Volume

17

Issue

17

Number of Pages

4240-4243

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/acs.orglett.5b02031

Copyright Status

Unknown

Socpus ID

84940984560 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84940984560

STARS Citation

Zheng, Yongsheng; Cleaveland, Jacob; Richardson, David; and Yuan, Yu, "An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure-Activity Relationship (Sar) Study At C2 Position" (2015). Scopus Export 2015-2019. 841.
https://stars.library.ucf.edu/scopus2015/841