Ixekizumab Treatment Shows A Neutral Impact On Cardiovascular Parameters In Patients With Moderate-To-Severe Plaque Psoriasis: Results From Uncover-1, Uncover-2, And Uncover-3

Keywords

cardiovascular; cholesterol; hsCRP; IL-17A; ixekizumab; psoriasis; UNCOVER

Abstract

Background: The impact of ixekizumab treatment for psoriasis on cardiovascular-related parameters in patients is unknown. Objective: To investigate cardiovascular-related parameters in patients with psoriasis treated with ixekizumab. Methods: In phase 3 trials, patients with moderate-to-severe psoriasis were randomized and treated with placebo, ixekizumab, or etanercept during the induction period (weeks 0-12; UNCOVER-1, UNCOVER-2, and UNCOVER-3). At week 12, responders were rerandomized to receive placebo or ixekizumab through the maintenance period (weeks 12-60; UNCOVER-1 and UNCOVER-2). Laboratory measures (fasting lipid profiles, glucose level, or high-sensitivity C-reactive protein [hsCRP] level), weight, blood pressure, and electrocardiograms were obtained through 60 weeks. Results: Baseline parameters were within normal ranges with the exception of elevated triglyceride and hsCRP levels. After maintenance dosing, no significant changes were observed versus placebo for total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, triglyceride, apolipoprotein A1, apolipoprotein B, or fasting glucose levels or for systolic/diastolic blood pressure at 60 weeks. Importantly, low-density lipoprotein–to–high-density lipoprotein ratios remained stable during the induction and maintenance periods. HsCRP concentrations were significantly reduced versus placebo at 12 weeks and remained reduced at 60 weeks, although not significantly. Although transient changes were observed for some parameters during the induction period, these changes did not persist into the maintenance period. Limitations: A lack of echocardiogram evaluations. Conclusions: Ixekizumab had a neutral impact on cardiovascular-related parameters in patients with psoriasis.

Publication Date

7-1-2018

Publication Title

Journal of the American Academy of Dermatology

Volume

79

Issue

1

Number of Pages

104-10900000000

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.jaad.2018.02.074

Socpus ID

85047192514 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85047192514

This document is currently not available here.

Share

COinS