Nanoreactors Based On Dnazyme-Functionalized Magnetic Nanoparticles Activated By Magnetic Field

Abstract

A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.

Publication Date

1-21-2018

Publication Title

Nanoscale

Volume

10

Issue

3

Number of Pages

1356-1365

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/c7nr08581h

Socpus ID

85040907071 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85040907071

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