Cerium Oxide Nanoparticles Inhibit Map Kinases Activation In The Retina Of Vldlr Mouse Model Of Age-Related Macular Degeneration

Keywords

Age-related macular degeneration; Cerium oxide nanoparticles; MAP kinases; Retina; Vldlr

Abstract

Age-related macular degeneration (AMD) damages the central region of the retina and is the leading cause of blindness in the elderly. The retina provides an ideal environment for the generation of toxic reactive oxygen species (ROS) and resultant oxidative damage due to the retina’s specific anatomical and metabolic characteristics. Decreasing ROS is, therefore, a target in the prevention and treatment of AMD. Cerium oxide nanoparticles or nanoceria are antioxidants that catalytically scavenge ROS. We have previously shown that a single intravitreal injection of nanoceria into the eye of a P28 Vldlr-/-mouse, an AMD model, inhibits the activation of mitogen-activated protein (MAP) kinases ERK, JNK, and p38 within one week. In this study we extended the endpoint for analysis to 3 months and demonstrated that injection of nanoceria in P28 Vldlr-/-mice produced sustained inhibition of the three MAP kinases down to the level of control wild type mice.

Publication Date

1-1-2018

Publication Title

Comptes Rendus de L'Academie Bulgare des Sciences

Volume

71

Issue

11

Number of Pages

1488-1494

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.7546/CRABS.2018.11.07

Socpus ID

85064038988 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85064038988

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