A Highly Stereoselective And Scalable Synthesis Of L -Allo-Enduracididine

Abstract

A highly stereoselective and scalable synthesis of l-allo-enduracididine from hydroxyproline derivative is described. Pyrrolidine oxidation and reductive ring opening are the key steps in the synthesis. Compared to previously reported approaches, the current route affords l-allo-enduracididine in 10 steps from 3 in 31% overall yield with >50:1 diastereoselectivity.

Publication Date

9-18-2015

Publication Title

Organic Letters

Volume

17

Issue

18

Number of Pages

4620-4623

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/acs.orglett.5b02362

Socpus ID

84941887876 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84941887876

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