A Highly Stereoselective And Scalable Synthesis Of L -Allo-Enduracididine
Abstract
A highly stereoselective and scalable synthesis of l-allo-enduracididine from hydroxyproline derivative is described. Pyrrolidine oxidation and reductive ring opening are the key steps in the synthesis. Compared to previously reported approaches, the current route affords l-allo-enduracididine in 10 steps from 3 in 31% overall yield with >50:1 diastereoselectivity.
Publication Date
9-18-2015
Publication Title
Organic Letters
Volume
17
Issue
18
Number of Pages
4620-4623
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1021/acs.orglett.5b02362
Copyright Status
Unknown
Socpus ID
84941887876 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84941887876
STARS Citation
Craig, William; Chen, Janet; Richardson, David; Thorpe, Rondel; and Yuan, Yu, "A Highly Stereoselective And Scalable Synthesis Of L -Allo-Enduracididine" (2015). Scopus Export 2015-2019. 893.
https://stars.library.ucf.edu/scopus2015/893